Alberto Aquilani, Albert Riera and Martin Skrtel all drop to the bench to make way for the three changes Rafa Benitez has made to the starting line-up for the latest derby.
Daniel Agger returns to the back four where Jamie Carragher again starts at right-back, Lucas returns to the midfield alongside Mascherano.
Maxi Rodriguez also starts, presumably helping Dirk Kuyt and Steven Gerrard support David Ngog up front.
Liverpool: Reina, Carragher, Kyrgiakos, Agger, Insua, Lucas, Mascherano, Kuyt, Gerrard, Maxi, Ngog
Subs: Cavalieri, Aquilani, Riera, Aurelio, Babel, Degen, Skrtel
Everton: Howard, Baines, Heitinga, Distin, Neville, Donovan, Cahill, Pienaar, Osman, Fellaini, Saha
Subs: Nash, Senderos, Coleman, Bilyaletdinov, Arteta, Yakubu, Anichebe
Referee: Martin Atkinson
Assistant referees: David Richardson & Darren Cann
Fourth official: Andre Marriner