Rafa Benitez has made changes to the side that lost to Arsenal on Monday, at least two of them enforced.
Glen Johnson is out of the squad completely, Fernando Torres restricted to the bench.
Pepe Reina is in goal and after that it waits to be seen just how Rafa intends to line the players up.
Skrtel joins Carragher and Agger as the centre-backs starting the game, which could suggest Rafa is starting with three at the back.
Another option of course is that Carragher will move to right back in a more conventional back-four with the returning Emiliano Insua on the opposite side of the pitch.
With Lucas on the bench it’s possible that Steven Gerrard will start alongside Mascherano in the centre of midfield, with Kuyt partnering Ngog upfront. Aquilani is on the bench again.
Liverpool desperately need to win the game and win it in style to restore some confidence.
Liverpool: 25 Reina, 5 Agger, 12 Aurelio, 22 Insua, 23 Carragher, 37 Skrtel, 8 Gerrard, 15 Benayoun, 20 Mascherano, 18 Kuyt, 24 Ngog
Subs: 1 Cavalieri, 16 Kyrgiakos, 32 Darby, 38 Dossena, 4 Aquilani, 21 Lucas, 9 Torres
Wigan: 1 Kirkland, 7 Scharner, 17 Boyce, 19 Bramble, 25 Melchiot, 31 Figueroa, 6 Thomas, 14 N’Zogbia, 15 Gomez, 27 Diame, 20 Rodallega
Subs: 22 Kingson, 4 Amaya, 5 Cho, 10 Koumas, 16 Sinclair, 18 De Ridder, 9 Scotland